Ara Toshiaki, Nakatani Sachie, Kobata Kenji, Sogawa Norio, Sogawa Chiharu
Department of Dental Pharmacology, Matsumoto Dental University, 1780 Gobara Hirooka, Shiojiri 399-0781, Japan.
Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Medicines (Basel). 2018 Nov 13;5(4):122. doi: 10.3390/medicines5040122.
The oral inflammatory diseases are divided into two types: acute and chronic inflammatory diseases. In this review, we summarize the biological efficacy of herbal medicine, natural products, and their active ingredients against acute and chronic inflammatory diseases in the oral region, especially stomatitis and periodontitis. We review the effects of herbal medicines and a biscoclaurin alkaloid preparation, cepharamthin, as a therapy against stomatitis, an acute inflammatory disease. We also summarize the effects of herbal medicines and natural products against periodontitis, a chronic inflammatory disease, and one of its clinical conditions, alveolar bone resorption. Recent studies show that several herbal medicines such as kakkonto and ninjinto reduce LPS-induced PGE 2 production by human gingival fibroblasts. Among herbs constituting these herbal medicines, shokyo () and kankyo () strongly reduce PGE 2 production. Moreover, anti-osteoclast activity has been observed in some natural products with anti-inflammatory effects used against rheumatoid arthritis such as carotenoids, flavonoids, limonoids, and polyphenols. These herbal medicines and natural products could be useful for treating oral inflammatory diseases.
急性和慢性炎性疾病。在本综述中，我们总结了草药、天然产物及其活性成分对口腔区域急性和慢性炎性疾病，尤其是口腔炎和牙周炎的生物学功效。我们综述了草药和一种双环异喹啉生物碱制剂西法辛作为治疗口腔炎（一种急性炎性疾病）的效果。我们还总结了草药和天然产物对牙周炎（一种慢性炎性疾病）及其临床病症之一牙槽骨吸收的影响。最近的研究表明，诸如葛根汤和人参汤等几种草药可减少人牙龈成纤维细胞中脂多糖诱导的前列腺素E2生成。在构成这些草药的草药中，干姜（）和汉防己（）强烈减少前列腺素E2生成。此外，在一些用于治疗类风湿性关节炎的具有抗炎作用的天然产物如类胡萝卜素、黄酮类化合物、柠檬苦素和多酚中观察到了抗破骨细胞活性。这些草药和天然产物可能有助于治疗口腔炎性疾病。
