绞股蓝对γ射线辐照小鼠的保护作用。

Protective effects of Gynostemma pentaphyllum in gamma-irradiated mice.

作者信息

Chen W C, Hau D M, Chen K T, Wang M I, Lin I H

机构信息

Institute of Radiation Biology, National Tsing-Hua University, Hsin Chu, Taiwan.

出版信息

Am J Chin Med. 1996;24(1):83-92. doi: 10.1142/S0192415X96000116.

DOI:10.1142/S0192415X96000116

PMID:8739185

Abstract

Radiation protective effects of Gynostemma Pentaphyllum (Gp) were investigated in gamma-irradiated mice. Animals were sacrificed on days 5, 15, 25 and 35 after gamma-irradiation. GOT, GPT, serum IgG and leukocyte counts were measured. Proliferation of splenocytes stimulated by mitogens, such as PHA, Con A, and LPS were detected and compared. The results showed that all parameters measured in this study were decreased and proliferation of splenocytes stimulated by mitogens were repressed in gamma-irradiated mice. Gp helped to recover the decreased leukocyte counts, GOT, GPT and IgG in serum and the proliferation of splenocytes stimulated by PHA, LPS and Con A in the gamma-ray irradiated mice.

摘要

在经γ射线照射的小鼠中研究了绞股蓝（Gp）的辐射防护作用。在γ射线照射后的第5、15、25和35天处死动物。测量谷草转氨酶（GOT）、谷丙转氨酶（GPT）、血清免疫球蛋白G（IgG）和白细胞计数。检测并比较了由促细胞分裂剂（如植物血凝素（PHA）、刀豆蛋白A（Con A）和脂多糖（LPS））刺激的脾细胞增殖情况。结果表明，本研究中测量的所有参数均降低，且γ射线照射小鼠中由促细胞分裂剂刺激的脾细胞增殖受到抑制。绞股蓝有助于恢复γ射线照射小鼠血清中降低的白细胞计数、GOT、GPT和IgG以及由PHA、LPS和Con A刺激的脾细胞增殖。