绞股蓝皂苷对γ射线辐照小鼠细胞免疫的影响。
Effects of gypenosides on cellular immunity of gamma-ray-irradiated mice.
作者信息
Hau D M, Feng Y, Chen W C, Lin I H, Chen K T, Lin S S, Wang M I
机构信息
Institute of Radiation Biology, National Tsing-Hua University, Taiwan.
出版信息
Chin Med J (Engl). 1996 Feb;109(2):143-6.
OBJECTIVE
To investigate the effects of gypenosides (Gs) on cellular immunocompetence in the gamma-ray-irradiated mice.
MATERIALS AND METHODS
Tested mice of ICR strain were treated continuously with Gs for 10 days before or after 4 Gy gamma-irradiation. Body weight and splenic weight of mice were measured. The blastogenic response of splenocytes to mitogens, such as PHA, Con A and LPS were also detected. The cellular immunocompetence was measured by 3H-thymidine incorporation in each tested mouse.
RESULTS
Body weight as well as splenic weight decreased in gamma-ray-irradiated mice. The blastogenic responses of splenocytes to mitogens were inhibited after gamma-ray irradiation. To treat with Gs was effective to enhance the recovery of body weight, splenic weight and immunocompetence in gamma-ray-irradiated mice from radiation damage.
CONCLUSIONS
Four Gy gamma-ray irradiation could decrease splenic weight and cellular immunocompetence of mice. Gs could help the recovery of the splenic weight and cellular immunocompetence in gamma-ray-irradiated mice.
目的
研究绞股蓝总皂苷（Gs）对γ射线照射小鼠细胞免疫能力的影响。
材料与方法
将ICR品系的受试小鼠在4 Gyγ射线照射前或照射后连续10天给予Gs处理。测量小鼠的体重和脾脏重量。还检测了脾细胞对丝裂原（如PHA、Con A和LPS）的增殖反应。通过对每只受试小鼠进行3H-胸腺嘧啶核苷掺入来测定细胞免疫能力。
结果
γ射线照射小鼠的体重和脾脏重量均下降。γ射线照射后脾细胞对丝裂原的增殖反应受到抑制。给予Gs治疗可有效促进γ射线照射小鼠从辐射损伤中恢复体重、脾脏重量和免疫能力。
结论
4 Gyγ射线照射可降低小鼠的脾脏重量和细胞免疫能力。Gs有助于γ射线照射小鼠恢复脾脏重量和细胞免疫能力。
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