Song C, Leonard B E
Department of Pharmacology, University College, Galway, Ireland.
Neuroimmunomodulation. 1995 Sep-Oct;2(5):263-73. doi: 10.1159/000097205.
The macrophage theory of depression proposes that abnormal secretions of the macrophage cytokines, an increase in interleukin (IL) 1, and a decrease in IL-2 may cause depression. The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the present study, the effects of intracerebroventricular administration of IL-2 (10 U) for 7 days on behaviour, neurotransmitter concentrations, corticosterone levels, and some immune functions were investigated. In the novel environment of the 'open-field' apparatus, the OB rat showed increases in ambulation, rearing, grooming, and defaecation scores as compared with sham-operated animals. Following IL-2 administration, grooming and defaecation were significantly attenuated, while the ambulation and rearing scores were unaffected. In the elevated plus-maze, the increase in the time spent on the open arms of the maze by the OB animal was normalized by IL-2 administration. In the brain of untreated OB rats, the concentrations of noradrenaline were reduced; IL-2 treatment significantly increased the concentrations of noradrenaline and serotonin. After administration of IL-2 for 7 days, the impairments in the immune functions were also largely reversed in OB rats. Thus IL-2 significantly normalized the hyperactivity of mononuclear cells, the suppression of lymphocyte proliferation, and the reduction in the monocyte percentage in the white blood cell count in the OB rat. The concentrations of corticosterone in the serum of the OB rat were significantly reduced, but returned to control values following IL-2 treatment. The results suggest that IL-2 may have modulatory functions on behavioural, neurochemical, hormonal, and immunological aspects of the OB rat model of depression.
抑郁症的巨噬细胞理论提出，巨噬细胞细胞因子分泌异常、白细胞介素（IL）-1增加和IL-2减少可能导致抑郁症。嗅球切除（OB）大鼠已被开发为抑郁症的动物模型。在本研究中，研究了脑室内注射IL-2（10 U）7天对行为、神经递质浓度、皮质酮水平和一些免疫功能的影响。在“旷场”装置的新环境中，与假手术动物相比，OB大鼠的行走、直立、梳理和排便得分增加。给予IL-2后，梳理和排便明显减弱，而行走和直立得分不受影响。在高架十字迷宫中，OB动物在迷宫开放臂上花费时间的增加通过给予IL-2恢复正常。在未经治疗的OB大鼠脑中，去甲肾上腺素浓度降低；IL-2治疗显著增加了去甲肾上腺素和血清素的浓度。给予IL-2 7天后，OB大鼠的免疫功能损伤也在很大程度上得到逆转。因此，IL-2显著使OB大鼠的单核细胞过度活跃、淋巴细胞增殖受抑制以及白细胞计数中单核细胞百分比降低恢复正常。OB大鼠血清中皮质酮的浓度显著降低，但在IL-2治疗后恢复到对照值。结果表明，IL-2可能对抑郁症OB大鼠模型的行为、神经化学、激素和免疫学方面具有调节作用。
