Song C, Earley B, Leonard B E
Department of Pharmacology, University College, Galway, Ireland.
Eur Neuropsychopharmacol. 1996 Aug;6(3):157-62. doi: 10.1016/0924-977x(95)00073-x.
The effects of chronic treatment with the non-sedative histamine H1 receptor antagonist terfenadine (5 mg/kg, i.p.) for 16 days on some behavioural and immunological parameters were studied in the olfactory bulbectomized (OB) rat model of depression. In the open field apparatus, OB rats showed a significant increase in ambulation and rearing scores. Following terfenadine treatment, this hyperactivity was significantly attenuated. In untreated OB rats, neutrophils phagocytosis and lymphocyte proliferation were significantly suppressed. Terfenadine administration markedly reversed the suppression of these immunological parameters in the treated OB animals, but did not reverse the abnormalities in the differential white blood cell count caused by bulbectomy. These results suggest that the histamine H1 receptor antagonist terfenadine may have antidepressant properties and that terfenadine is effective in reversing some of behavioural and immune changes in the olfactory bulbectomized rat model of depression.
在嗅球切除（OB）抑郁症大鼠模型中，研究了非镇静性组胺H1受体拮抗剂特非那定（5毫克/千克，腹腔注射）连续治疗16天对一些行为和免疫参数的影响。在旷场实验装置中，OB大鼠的行走和直立得分显著增加。特非那定治疗后，这种多动明显减轻。在未治疗的OB大鼠中，中性粒细胞吞噬作用和淋巴细胞增殖受到显著抑制。特非那定给药显著逆转了治疗的OB动物中这些免疫参数的抑制，但未逆转嗅球切除引起的白细胞分类计数异常。这些结果表明，组胺H1受体拮抗剂特非那定可能具有抗抑郁特性，并且特非那定在逆转嗅球切除抑郁症大鼠模型中的一些行为和免疫变化方面是有效的。
