Posner L, Mokrzycki M H
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Am J Nephrol. 1996;16(4):339-43. doi: 10.1159/000169020.
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use. The association of central diabetes insipidus (CDI) with lithium use is rare. We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI. To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently. Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed. This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.
肾性尿崩症（NDI）是锂使用过程中一种有充分文献记载的并发症。中枢性尿崩症（CDI）与锂使用之间的关联较为罕见。我们报告了一名接受慢性锂治疗的患者，该患者在潜在慢性NDI的背景下出现了短暂性CDI。据我们所知，这是首例锂相关性CDI和NDI同时出现的病例。文中讨论了锂相关性CDI病理生理学的潜在机制。该病例强调了通过直接测量血浆血管加压素，并结合同时测定的血浆和尿渗透压来评估锂相关性多尿的重要性，以确保正确诊断并确保适当的治疗管理。
