Kria L, Ohira A, Amemiya T
Department of Ophthalmology, Nagasaki University School of Medicine, Japan.
Acta Histochem. 1996 Apr;98(2):195-201. doi: 10.1016/s0065-1281(96)80038-9.
Some fibroangiogenic factors have recently been shown to play potential roles in fibrovascular diseases. The aim of this study was to examine whether there is any relationship between growth factors and pterygium genesis. Twenty-three primary pterygia and 4 normal conjunctiva specimens were analyzed by indirect immunohistochemistry using specific antibodies against basic fibroblast growth factor (b-FGF), platelet derived growth factor (PDGF), transforming growth factor-beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha). Positive immunostaining of these growth factors was located in the epithelial cells, endothelial cells of vessels, basement membranes of vessels and epithelium, fibroblasts and infiltrating inflammatory cells in the pterygium. In the normal conjunctiva, positive immunolabeling for TGF-beta and PDGF was much weaker than in the pterygium. We conclude that growth factors may interact directly or indirectly in the pathogenesis of pterygium although proof of this awaits further studies.
最近研究发现，一些促纤维血管生成因子在纤维血管疾病中发挥潜在作用。本研究旨在探讨生长因子与翼状胬肉发生之间是否存在关联。采用抗碱性成纤维细胞生长因子（b-FGF）、血小板衍生生长因子（PDGF）、转化生长因子-β（TGF-β）和肿瘤坏死因子-α（TNF-α）的特异性抗体，通过间接免疫组织化学法对23例原发性翼状胬肉标本和4例正常结膜标本进行分析。这些生长因子的阳性免疫染色位于翼状胬肉的上皮细胞、血管内皮细胞、血管基底膜和上皮、成纤维细胞以及浸润的炎性细胞中。在正常结膜中，TGF-β和PDGF的阳性免疫标记比翼状胬肉中弱得多。我们得出结论，生长因子可能在翼状胬肉的发病机制中直接或间接相互作用，尽管这一点尚待进一步研究证实。
