Vrecl M, Pogacnik A, Lorger J, Bavdek S V
Institute of Anatomy, Histology and Embryology, Veterinary Faculty, University of Ljubljana, Slovenia.
Pflugers Arch. 1996;431(6 Suppl 2):R213-4. doi: 10.1007/BF02346344.
The effects of the application of commercial low chlorinated PCB Pyralene-3000 on rat lung development during late gestation were studied. In the developing lungs (17.5 to 21.5 days) the volume density (Vv) of a particular compartment and length density of potential air spaces (Lv) were determined. Significant difference (p < 0.01) in epithelium to mesenchyme ratio (Epi/Mes) occurred between the control and treated groups on day 20.5 due to an increased volume proportion of mesenchyme (Vvmes) in the treated group suggesting a small delay in maturation. Decreased volume proportion of potential airspaces (Vvair) was observed on days 18.5 and 20.5. However, no differences were found on day 21.5 in any variables studied.
研究了商业低氯多氯联苯派拉林 - 3000在妊娠后期对大鼠肺发育的影响。在发育中的肺（17.5至21.5天）中，测定了特定隔室的体积密度（Vv）和潜在气腔的长度密度（Lv）。在第20.5天，对照组和处理组之间的上皮与间充质比例（Epi/Mes）出现显著差异（p < 0.01），这是由于处理组中间充质的体积比例（Vvmes）增加，表明成熟略有延迟。在第18.5天和第20.5天观察到潜在气腔的体积比例（Vvair）降低。然而，在第21.5天，所研究的任何变量均未发现差异。
