Popović M, Sketelj J, Bresjanac M
Institute of Pathology, Medical Faculty, University of Ljubljana, Slovenia.
Pflugers Arch. 1996;431(6 Suppl 2):R287-8. doi: 10.1007/BF02346381.
Axons and Schwann cells (SC) in the peripheral nerve (PN) are in permanent interaction. Both myelin-forming SC (MSC) and nonmyelin-forming SC (NMSC) have a defined antigenic phenotype. Four weeks after PN transection, the proliferating SC in the distal stump lose some of their antigens, they start to display antigenic profile of NMSC and, in addition, to reexpress nerve growth factor receptor (NGF-rec) and growth associated protein (GAP-43), two antigens of their precursor cells. It can be assumed that migrating SC may differ in their antigenic profile in regard to resident proliferated SC in denervated distal nerve stump. We found that many SC specific antigens (S-100 protein, glial fibrilary acidic protein-GFAP, NGF-rec, GAP-43) are down-regulated in migrating SC as compared to SC proliferating in situ in the absence of axons.
外周神经（PN）中的轴突与施万细胞（SC）处于持续相互作用中。形成髓鞘的施万细胞（MSC）和不形成髓鞘的施万细胞（NMSC）都具有特定的抗原表型。在PN横断四周后，远端残端中增殖的施万细胞会丢失一些抗原，开始呈现NMSC的抗原谱，此外，还会重新表达神经生长因子受体（NGF-rec）和生长相关蛋白（GAP-43），这两种是其前体细胞的抗原。可以推测，迁移的施万细胞在抗原谱方面可能与去神经支配的远端神经残端中驻留增殖的施万细胞不同。我们发现，与在无轴突情况下原位增殖的施万细胞相比，许多施万细胞特异性抗原（S-100蛋白、胶质纤维酸性蛋白-GFAP、NGF-rec、GAP-43）在迁移的施万细胞中表达下调。
