A型肉毒杆菌毒素中毒小鼠运动神经末梢降钙素基因相关肽的上调。
Upregulation of calcitonin gene-related peptide at mouse motor nerve terminals poisoned with botulinum type-A toxin.
作者信息
Meunier F A, Colasante C, Faille L, Gastard M, Molgó J
机构信息
Laboratoire de Neurobiologie Cellulaire et Moléculaire, C.N.R.S. (U.P.R.9040), Gif-sur-Yvette, France.
出版信息
Pflugers Arch. 1996;431(6 Suppl 2):R297-8. doi: 10.1007/BF02346386.
Calcitonin gene-related peptide (CGRP)-like immunoreactivity of motor nerve terminals was investigated at different times after local in vivo injection of botulinum type-A toxin (BoNT/A) close to the mouse levator auris longus muscle. CGRP expression in most of control nerve terminals was undetectable, but markedly increased during muscle paralysis and synaptic remodelling and, declined once functional recovery occurred.
在小鼠耳长肌附近局部体内注射A型肉毒杆菌毒素（BoNT/A）后的不同时间，研究了运动神经末梢中降钙素基因相关肽（CGRP）样免疫反应性。在大多数对照神经末梢中未检测到CGRP表达，但在肌肉麻痹和突触重塑期间显著增加，并且在功能恢复后下降。
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