Wickens A P, Thornton E W
Department of Psychology, University of Central Lancashire, Preston, UK.
Exp Brain Res. 1996 Apr;109(1):17-21. doi: 10.1007/BF00228622.
Apomorphine, 2 mg/kg (s.c.) produced significant contralateral turning in rats with unilateral radiofrequency lesions of the habenula nucleus over a test period of 60 min when tested at post-surgery days 3, 7, and 14. Levels of contralateral circling were not significantly increased when the animals were tested on days 21 and 28, although a contralateral bias was still observed. Rotation induced by apomorphine was completely blocked by the administration of haloperidol (0.3 mg/kg i.p.), and there was no behavioural asymmetry in lesioned animals following administration of saline or a high dose of haloperidol (2 mg/kg i.p.). These results indicate that unilateral habenula lesions lead to imbalance of dopaminergic activity, which is expressed as contralateral circling when the animal is challenged with apomorphine.
阿扑吗啡，2毫克/千克（皮下注射），在术后第3天、第7天和第14天进行测试时，对单侧缰核射频损伤的大鼠在60分钟的测试期内产生了显著的对侧旋转。在第21天和第28天对动物进行测试时，对侧转圈水平没有显著增加，尽管仍观察到对侧偏向。阿扑吗啡诱导的旋转被氟哌啶醇（0.3毫克/千克腹腔注射）完全阻断，在给予生理盐水或高剂量氟哌啶醇（2毫克/千克腹腔注射）后，损伤动物没有行为不对称。这些结果表明，单侧缰核损伤导致多巴胺能活动失衡，当动物用阿扑吗啡激发时，表现为对侧转圈。
