Skagerberg G, Lindvall O, Björklund A
Brain Res. 1984 Jul 30;307(1-2):99-108. doi: 10.1016/0006-8993(84)90465-7.
This study describes the organization of the mesohabenular dopamine (DA) system in the rat as revealed by fluorescence histochemistry in combination with lesions, DA uptake experiments and injections of a retrograde tracer. The DA axons were found to be aggregated in a dense terminal field located in the caudal two thirds of the medial part of the lateral habenular nucleus. Microknife lesions of the stria medullaris left this DA innervation unaffected while cuts through the fasciculus retroflexus resulted in the virtual disappearance of the DA innervation. Injections of the fluorescent retrograde tracer True Blue (TB) into the lateral habenula produced labeling of both DA and non-DA-containing cells in the ventral mesencephalon, mainly in the interfascicular nucleus ipsilateral to the injection. This study thus documents the existence of a mesohabenular DA pathway whose cell bodies are located in the ventral mesencephalon and whose axons ascend with the fasciculus retroflexus to terminate in the caudomedial part of the lateral habenular nucleus. This information, taken together with insights gained from other studies, suggests a role for the mesohabenular DA system in modulating telencephalic feedback onto the mesencephalic DA-neurons and also in regulating the output from the dorsal raphe nucleus.
本研究描述了大鼠中脑缰核多巴胺（DA）系统的组织结构，该结构通过荧光组织化学结合损伤实验、DA摄取实验以及逆行示踪剂注射得以揭示。DA轴突聚集于外侧缰核内侧部尾侧三分之二处的一个密集终末区。髓纹的微刀损伤并未影响该DA神经支配，而切断后屈束则导致DA神经支配几乎完全消失。向外侧缰核注射荧光逆行示踪剂真蓝（TB），可使中脑腹侧的DA和非DA细胞均出现标记，主要位于注射同侧的束间核。因此，本研究证实了中脑缰核DA通路的存在，其细胞体位于中脑腹侧，轴突随后屈束上行，终止于外侧缰核的尾内侧部。这些信息与其他研究的见解相结合，提示中脑缰核DA系统在调节端脑对中脑DA神经元的反馈以及调节背侧中缝核的输出方面发挥作用。
