Schmidt M L, Martin J A, Lee V M, Trojanowski J Q
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
Acta Neuropathol. 1996;91(5):475-81. doi: 10.1007/s004010050454.
Amygdalae of patients with Alzheimer's disease (AD), Parkinson's disease, Down's syndrome, diffuse Lewy body disease or a combination of these diseases were probed with antibodies to neurofilament proteins as well as with Lewy body (LB)- and paired helical filament-specific antibodies. The results indicate that the amygdala is severely affected by the accumulation of both neurofibrillary tangles (NFTs) and LBs in most cases of the diseases mentioned above, and that amygdala LBs have a similar epitope composition to that of LBs in the brain stem and cerebral cortex. While large numbers of both LBs and NFTs were seen in different neurons within the amygdala, these two lesions frequently occurred together in the same neurons of the amygdala. These findings are in contrast to other sites that accumulate LBs and NFTs, but rarely both lesions in the same neuron. Thus, amygdala neurons may be selectively vulnerable to developing both LBs and NFTs, and these inclusions may play a role in the massive degeneration of these neurons in AD and LB disorders of the elderly.
使用抗神经丝蛋白抗体以及路易小体（LB）和双螺旋丝特异性抗体，对患有阿尔茨海默病（AD）、帕金森病、唐氏综合征、弥漫性路易体病或这些疾病组合的患者的杏仁核进行检测。结果表明，在上述大多数疾病病例中，杏仁核受到神经原纤维缠结（NFTs）和路易小体积累的严重影响，并且杏仁核路易小体与脑干和大脑皮质中的路易小体具有相似的表位组成。虽然在杏仁核内的不同神经元中都观察到大量的路易小体和神经原纤维缠结，但这两种病变经常在杏仁核的同一神经元中同时出现。这些发现与其他积累路易小体和神经原纤维缠结的部位形成对比，在其他部位这两种病变很少出现在同一神经元中。因此，杏仁核神经元可能对路易小体和神经原纤维缠结的形成具有选择性易感性，并且这些包涵体可能在老年患者的AD和路易体疾病中这些神经元的大量退化中起作用。
