Routi T, Rönnemaa T, Jokinen E, Viikari J, Niinikoski H, Leino A, Simell O
Cardiorespiratory Research Unit, University of Turku, Finland.
Acta Paediatr. 1996 Apr;85(4):407-12. doi: 10.1111/j.1651-2227.1996.tb14051.x.
The correlation between lipoprotein(a) (Lp(a)) concentrations in children aged 7-24 months and their family members was determined and the association between the Lp(a) values of the children and a family history of coronary heart disease (CHD) was assessed. The Lp(a) values of the children correlated strongly with midparent Lp(a) values as early as at 7 months of age (r = 0.54 to 0.59, p < 0.0001). This correlation was stronger than the correlation of serum total cholesterol and total cholesterol corrected for Lp(a)-cholesterol between children and parents. None of the parents had CHD. The median Lp(a) concentration of the parents with a family history of CHD was significantly higher than that of parents with no such history (111 vs 87 mg/1, p = 0.024). However, the children's Lp(a) levels were not associated with CHD in their grandparents. The genetic dependence of the Lp(a) concentration is already evident in infancy. The Lp(a) concentration in young parents, but not in their 24-month-old children, is associated with CHD in grandparents. This may be explained by a dilution of the genetic influence on Lp(a) over two generations.
测定了7至24个月大儿童及其家庭成员的脂蛋白(a) [Lp(a)]浓度之间的相关性，并评估了儿童Lp(a)值与冠心病(CHD)家族史之间的关联。早在7个月大时，儿童的Lp(a)值就与父母平均Lp(a)值密切相关(r = 0.54至0.59，p < 0.0001)。这种相关性比儿童与父母之间血清总胆固醇以及校正Lp(a)胆固醇后的总胆固醇的相关性更强。父母均无冠心病。有冠心病家族史的父母的Lp(a)浓度中位数显著高于无此家族史的父母(111对87 mg/1，p = 0.024)。然而，儿童的Lp(a)水平与其祖父母的冠心病并无关联。Lp(a)浓度的遗传依赖性在婴儿期就已很明显。年轻父母的Lp(a)浓度与祖父母的冠心病有关，而24个月大儿童的Lp(a)浓度则不然。这可能是由于遗传对Lp(a)的影响在两代人之间被稀释所致。
