白色念珠菌第三个几丁质酶基因（CHT1）的分子克隆
Molecular cloning of a third chitinase gene (CHT1) from Candida albicans.
作者信息
McCreath K J, Specht C A, Liu Y, Robbins P W
机构信息
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
Yeast. 1996 Apr;12(5):501-4. doi: 10.1002/(SICI)1097-0061(199604)12:5%3C501::AID-YEA931%3E3.0.CO;2-U.
Here we report the complete nucleotide sequence of a third chitinase gene (CHT1) from the dimorphic human pathogen Candida albicans. The deduced amino acid (aa) sequence of Cht1 consists of 416 aa and displays 36% protein sequence similarity to chitinases Cht2 and Cht3, from C. albicans. Interestingly the domain structure of Cht1 is truncated when compared to the other chitinases of C. albicans and lacks a Ser/Thr-rich region.
在此，我们报道了来自二态性人类病原体白色念珠菌的第三个几丁质酶基因（CHT1）的完整核苷酸序列。Cht1推导的氨基酸序列由416个氨基酸组成，与白色念珠菌的几丁质酶Cht2和Cht3的蛋白质序列相似性为36%。有趣的是，与白色念珠菌的其他几丁质酶相比，Cht1的结构域结构被截断，并且缺少富含丝氨酸/苏氨酸的区域。
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