Exercise and cancer: linkages with obesity?

This review examines possible protection against various types of tumors from both occupational and leisure-time physical activity. A growing number of well-controlled studies suggest that both hard physical work and an active leisure reduce the overall incidence of cancer. Benefit is demonstrated most clearly for colonic tumors; here, benefit persists after control of the data for body mass index, and a likely mechanism is the speeding of colonic transit, with a resulting decrease in exposure to carcinogens. There are occasional reports of protection against tumors of the breast, reproductive tract, and other body organs. In some of these latter sites, potential mechanisms of protection include a suppression of sex hormone secretion and reduction of body fat depots, where androgens are converted to toxic estrogen derivatives. While vigorous athletic participation may well modulate hormone output, a reduction of body fat is a more likely explanation of any benefit from more moderate physical activity. Protection against cancer is unlikely to become a major argument for an active lifestyle, but it is nevertheless a useful byproduct of physical activity undertaken with other health objectives.