氧化修饰低密度脂蛋白与动脉粥样硬化：一个不断演变的似是而非的情形。

Oxidatively modified LDL and atherosclerosis: an evolving plausible scenario.

作者信息

Jialal I, Fuller C J

机构信息

Center for Human Nutrition, University of Texas--Southwestern Medical Center, Dallas 75235-9052, USA.

出版信息

Crit Rev Food Sci Nutr. 1996 Apr;36(4):341-55. doi: 10.1080/10408399609527729.

DOI:10.1080/10408399609527729

PMID:8740438

Abstract

Much evidence has accumulated that implicates the oxidative modification of low-density lipoprotein (LDL) in the early stages of atherogenesis. The antioxidant nutrients alpha-tocopherol, ascorbic acid, and betacarotene have been shown to inhibit in vitro LDL oxidation. In addition, they have been shown to increase the resistance of LDL to oxidation when given to animals and humans. Because plasma levels of these nutrients can be increased by dietary supplementation with minimal side effects, they may show promise in the prevention of coronary artery disease.

摘要

大量证据表明，低密度脂蛋白（LDL）的氧化修饰与动脉粥样硬化的早期阶段有关。抗氧化营养素α-生育酚、抗坏血酸和β-胡萝卜素已被证明在体外可抑制LDL氧化。此外，给动物和人类服用这些营养素后，它们还能提高LDL的抗氧化能力。由于通过饮食补充这些营养素可提高血浆水平，且副作用最小，因此它们在预防冠状动脉疾病方面可能具有前景。