Klatt P, Esterbauer H
Institute of Biochemistry, University of Graz, Austria.
J Cardiovasc Risk. 1996 Aug;3(4):346-51. doi: 10.1177/174182679600300402.
The oxidative hypothesis of atherogenesis suggests that an important event in the development of atherosclerotic lesions is the oxidation of lipids contained in low-density lipoprotein (LDL). This hypothesis is supported by a number of in-vitro and in-vivo studies demonstrating the proatherogenic properties of oxidized LDL, the occurrence of oxidatively modified LDL in atherosclerotic lesions and the reduction of atherosclerotic events by antioxidants.
动脉粥样硬化发生的氧化假说认为，动脉粥样硬化病变发展过程中的一个重要事件是低密度脂蛋白（LDL）中所含脂质的氧化。这一假说得到了多项体外和体内研究的支持，这些研究表明氧化型LDL具有促动脉粥样硬化特性、动脉粥样硬化病变中存在氧化修饰的LDL以及抗氧化剂可减少动脉粥样硬化事件。
