人类皮肤中谱系特异性钙调神经磷酸酶19（CaN19）的表达：正常黑素细胞中无表达。

Lineage-specific CaN19 expression in human skin: lack of expression in normal melanocytes.

作者信息

Andersen L B, Xia L, Stoll S, Zhao X, Elder J T

机构信息

Department of Dermatology, University of Michigan, Ann Arbor 48109-0314, USA.

出版信息

J Dermatol Sci. 1996 Apr;12(1):69-72. doi: 10.1016/0923-1811(95)00497-1.

DOI:10.1016/0923-1811(95)00497-1

PMID:8740464

Abstract

Although expression of CaN19 is reduced in cell lines derived from tumors of diverse origin, its expression in their normal counterparts has not been studied in detail. We find that CaN19 mRNA is expressed at very low to undetectable levels in normal melanocytes as well as malignant melanoma cell lines, confirming that CaN19 expression in normal cells is lineage-dependent.

摘要

尽管CaN19在源自多种肿瘤的细胞系中表达降低，但其在相应正常细胞中的表达尚未得到详细研究。我们发现，CaN19 mRNA在正常黑素细胞以及恶性黑色素瘤细胞系中的表达水平非常低甚至无法检测到，这证实了正常细胞中CaN19的表达具有谱系依赖性。