Westerhuis L W, Venekamp W J
Department of Clinical Chemistry, Ziekenhuis De Wever & Gregorius, Heerien The Netherlands.
Clin Biochem. 1996 Jun;29(3):255-9. doi: 10.1016/0009-9120(96)00002-5.
Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established.
In our study Lp(a) was measured in a large group of diabetiee (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively.
Statistically significant differences between Lp(a) levels in IDDM and NIDDM-and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM.
These results suggest that the level of Lp(a) in serum is not influenced by diabetes mellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.
文献中关于糖尿病患者脂蛋白-a（Lp(a)）水平的结果相互矛盾。有正常、升高和降低值的描述，且与糖代谢控制的关系尚未明确确立。
在我们的研究中，对一大组糖尿病患者（80例胰岛素依赖型糖尿病患者和90例非胰岛素依赖型糖尿病患者）测定了Lp(a)，并将其与糖代谢控制以及微量白蛋白尿、视网膜病变和/或神经病变的存在情况相关联。分别通过糖化血红蛋白（HbA1）和果糖胺测定评估长期和短期糖代谢控制情况。
无法确定胰岛素依赖型糖尿病和非胰岛素依赖型糖尿病患者以及110名健康非糖尿病对照组之间Lp(a)水平的统计学显著差异。似乎胰岛素依赖型糖尿病和非胰岛素依赖型糖尿病患者的Lp(a)水平与短期和长期糖代谢控制或微量白蛋白尿、神经病变或视网膜病变的发生无关。然而，糖代谢控制不佳影响了胰岛素依赖型糖尿病患者中Lp(a)水平高于0.25 g/L阈值的数量。
这些结果表明，血清中Lp(a)水平不受糖尿病、血糖控制或微量白蛋白尿、神经病变或视网膜病变发生情况的影响。
