Fonzo D, Angeli A, Sivieri R, Andriolo S, Frajria R, Ceresa F
J Clin Endocrinol Metab. 1977 Jul;45(1):164-8. doi: 10.1210/jcem-45-1-164.
Pasma prolactin response to the acute injection of sulpiride (1.5 mg/k BW im) was measured at 0800-0900h in 4 girls with idiopathic precocious puberty before and after 6 to 11 months of continuous therapy with 50 mg daily of cyproterone acetate (CA) orally administered. Two additional girls were examined after 26 and 28 months of therapy, respectively. Mean baseline prolactin concentrations were significantly higher in untreated girls with precocious puberty as compared to that of normal controls of the same chronological age and of a comparable degree of sexual maturation (14.5 +/- 1.9 SE vs. 7.4 +/- 1.8 SE ng/ml and vs. 9.5 +/- 1.8 ng/ml, respectively; P less than .02). Treatment with CA caused a significant further increase of plasma prolactin concentration (P less than .02 as compared to pre-treatment values); no correlation was observed between prolactin concentration and duration of treatment. No significant change in the integrated areas of prlactin response to sulpiride occurred after prolonged CA therapy. The results suggest that in idiopathic precocious puberty the action of CA upon the hypothalamic-hypophyseal complex is not solely antigonadotropic and that prolactin secretion is enhanced in patients given this drug.
在上午08:00 - 09:00，对4名患有特发性性早熟的女孩，在口服每日50毫克醋酸环丙孕酮（CA）连续治疗6至11个月前后，测量了血浆催乳素对急性注射舒必利（1.5毫克/千克体重，肌肉注射）的反应。另外两名女孩分别在治疗26个月和28个月后接受了检查。与相同实足年龄且性成熟程度相当的正常对照相比，未经治疗的性早熟女孩的平均基线催乳素浓度显著更高（分别为14.5±1.9标准误对7.4±1.8标准误纳克/毫升以及对9.5±1.8纳克/毫升；P＜0.02）。CA治疗导致血浆催乳素浓度进一步显著升高（与治疗前值相比，P＜0.02）；未观察到催乳素浓度与治疗持续时间之间的相关性。长期CA治疗后，催乳素对舒必利反应的积分面积无显著变化。结果表明，在特发性性早熟中，CA对下丘脑 - 垂体复合体的作用并非仅仅是抗促性腺激素的，并且给予该药物的患者催乳素分泌会增强。
