Descamps V, Duffour M T, Mathieu M C, Fernandez N, Cordier L, Abina M A, Kremer E, Perricaudet M, Haddada H
Génétique des virus oncogènes, Institut Gustave Roussy, Villejuif, France.
J Mol Med (Berl). 1996 Apr;74(4):183-9. doi: 10.1007/BF00204748.
Modification of tumor cells using gene transfer either to enhance host immunity or to act directly on tumor cells is being intensively studied in animal models. Remarkable results have yielded to approved clinical protocols in the treatment of cancer patients using this approach. Several methods of gene delivery have been developed. This article is particularly devoted to the interest of the use of adenoviral vectors in the different strategies of cancer gene therapy.
利用基因转移修饰肿瘤细胞以增强宿主免疫力或直接作用于肿瘤细胞，这一研究在动物模型中正在深入进行。在使用这种方法治疗癌症患者的临床方案中已经取得了显著成果并获得批准。已经开发出几种基因递送方法。本文特别致力于探讨腺病毒载体在癌症基因治疗的不同策略中的应用价值。
