马驹肺部病变中马红球菌毒力相关抗原的免疫组织化学检测
Immunohistochemical detection of virulence-associated antigens of Rhodococcus equi in pulmonary lesions of foals.
作者信息
Madarame H, Takai S, Morisawa N, Fujii M, Hidaka D, Tsubaki S, Hasegawa Y
机构信息
Department of Laboratory Animal Science, School of Veterinary Medicine and Animal Sciences, Kitasato University, Japan.
出版信息
Vet Pathol. 1996 May;33(3):341-3. doi: 10.1177/030098589603300312.
Rhodococcus equi was isolated from the lungs of six foals with bronchopneumonia. All isolates expressed 15-17-kd antigens by immunoblot analysis and contained a virulence-associated plasmid of 85 or 90 kb. Immunohistochemically, R. equi from all pulmonary lesions showed the expression of 15-17-kd antigens mainly in the phagocytic cells. The specific monoclonal antibody to 15-17-kd antigens of R. equi (MAb 10G5) may be an aid in the diagnosis of R. equi-induced pneumonia.
从六匹患支气管肺炎的幼驹的肺中分离出了马红球菌。通过免疫印迹分析，所有分离株均表达15 - 17kd抗原，并含有一个85或90kb的毒力相关质粒。免疫组织化学分析显示，所有肺部病变中的马红球菌15 - 17kd抗原主要在吞噬细胞中表达。针对马红球菌15 - 17kd抗原的特异性单克隆抗体（单克隆抗体10G5）可能有助于诊断马红球菌引起的肺炎。
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