Sartin E A, Herrera G A, Wilkins L P, Wolfe D F
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Vet Pathol. 1996 May;33(3):362-5. doi: 10.1177/030098589603300319.
A metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in an adult cow is described. The left lumbosacral plexus was obliterated by a mass which extended through the intervertebral foramen into the spinal canal and between the dorsal arches of the fifth and sixth lumbar vertebrae. A closely associated (possibly contiguous) mass extended into and separated the left sacroiliac joint. Multiple similar masses involved peripheral nerves and skeletal muscles of the pelvis, pelvic limbs, and abdominal wall. Metastatic lesions were scattered throughout the lungs. The lumbosacral lesion and all other masses consisted of interwoven bundles of loosely cohesive, elongated cells separated by variable collagenous matrix. Many neoplastic cells were positive for S-100 protein. Ultrastructurally, fibroblastic cells were mixed with scattered cells possessing schwannian characteristics.
描述了一例成年母牛腰骶丛转移性多中心神经纤维肉瘤。左侧腰骶丛被一个肿块阻塞，该肿块穿过椎间孔延伸至椎管，并位于第五和第六腰椎的背侧弓之间。一个紧密相连（可能连续）的肿块延伸至左骶髂关节并将其分开。多个类似肿块累及骨盆、盆腔肢体和腹壁的周围神经和骨骼肌。转移性病变散布于整个肺部。腰骶部病变及所有其他肿块均由交织成束的、松散黏附的细长细胞组成，细胞束被可变的胶原基质分隔。许多肿瘤细胞S-100蛋白呈阳性。超微结构上，成纤维细胞与散在的具有雪旺细胞特征的细胞混合存在。
