Laboratorio de Biología Celular y Molecular Aplicada, Instituto de Ciencias Veterinarias del Litoral, Universidad Nacional del Litoral/Consejo Nacional de Investigaciones Científicas y Técnicas, Esperanza, Santa Fe, Argentina; Laboratorio de Anatomía Patológica, Hospital de Salud Animal, Facultad de Ciencias Veterinarias de la Universidad Nacional del Litoral, Santa Fe, Argentina.
Laboratorio de Anatomía Patológica, Hospital de Salud Animal, Facultad de Ciencias Veterinarias de la Universidad Nacional del Litoral, Santa Fe, Argentina.
J Comp Pathol. 2024 Aug;213:41-45. doi: 10.1016/j.jcpa.2024.07.003. Epub 2024 Aug 6.
Reproductive problems in cattle are frequent and have an important impact on production. In addition, inflammatory, traumatic and other diseases may be followed by the development of tumours, which are a cause of culling of breeding males. The main types of tumours diagnosed in the bull penis are fibropapilloma and squamous cell carcinoma. The aim of this study was to characterize a case of a tumour in the glans penis of a bull from a dairy farm in Santa Fe, Argentina. The neoplastic tissue was stained with haematoxylin and eosin and then analysed by immunohistochemistry to reveal its characteristic phenotype. Results showed positivity to vimentin, neuron specific enolase, proliferating cell nuclear antigen, S100 and glial fibrillary acidic protein. This suggested that the tumour was a neoplasm of neural origin, classified as neurofibrosarcoma, a peripheral nerve sheath tumour, here reported in the penis of a bull for the first time.
牛的生殖问题很常见，对生产有重要影响。此外，炎症、创伤和其他疾病可能会导致肿瘤的发展，这也是淘汰繁殖公牛的原因之一。在公牛阴茎中诊断出的主要肿瘤类型是纤维乳头状瘤和鳞状细胞癌。本研究的目的是描述阿根廷圣达菲一个奶牛场公牛阴茎肿瘤的病例。使用苏木精和伊红对肿瘤组织进行染色，然后通过免疫组织化学分析来揭示其特征表型。结果显示波形蛋白、神经元特异性烯醇化酶、增殖细胞核抗原、S100 和神经胶质纤维酸性蛋白阳性。这表明肿瘤是一种神经来源的肿瘤，被归类为神经纤维肉瘤，这是一种周围神经鞘肿瘤，在此首次报道于公牛的阴茎中。
