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刺激大鼠大脑的特定区域会改变对新习得和旧习惯的记忆保持。

Stimulation of specific regions of brain in rats modifies retention for newly acquired and old habits.

作者信息

DeVietti T L, Kirkpatrick B R

出版信息

J Comp Physiol Psychol. 1977 Jun;91(3):662-73. doi: 10.1037/h0077343.

DOI:10.1037/h0077343
PMID:874127
Abstract

Three experiments were designed to investigate some effects of low-level stimulation of the amygdaloid complex (AMYG) and the mesencephalic reticular formation (MRF). Experiment 1 used a tilt box to test for motivational and/or reinforcement effects and failed to demonstrate these effects with stimulation of either structure. Experiment 2 used a one-trial fear-conditioning task and revealed that stimulation of the AMYG disrupted retention when given immediately after training or, under some conditions, 4 days after training. In the same task, Experiment 3 showed that stimulation of the MRF enhanced retention when given immediately after training or, under some conditions, 4 days after training. These data indicate that under these conditions, modification of retention by low-level stimulation of specific brain structures is independent of the age of the memory. Some implications of this result are discussed.

摘要

设计了三个实验来研究杏仁核复合体(AMYG)和中脑网状结构(MRF)的低水平刺激的一些效应。实验1使用倾斜箱来测试动机和/或强化效应,未能通过对任何一个结构的刺激证明这些效应。实验2使用一次性恐惧条件任务,结果显示,在训练后立即给予AMYG刺激或在某些条件下训练4天后给予刺激,会破坏记忆保持。在同一任务中,实验3表明,在训练后立即给予MRF刺激或在某些条件下训练4天后给予刺激,会增强记忆保持。这些数据表明,在这些条件下,特定脑结构的低水平刺激对记忆保持的改变与记忆的年龄无关。讨论了这一结果的一些含义。

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Stimulation of specific regions of brain in rats modifies retention for newly acquired and old habits.刺激大鼠大脑的特定区域会改变对新习得和旧习惯的记忆保持。
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