Otsuka N, Yoshitomi T, Tsuchiya K, Ukai K, Ooki C, Ishikawa S
Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.
Nippon Ganka Gakkai Zasshi. 1996 Jul;100(7):531-4.
The effect of topical application of prostaglandin-related compound isopropyl unoprostone on refraction and accommodation were examined. Topical application of isopropyl unoprostone obviously reduced the intraocular pressure, but no significant change in refraction was observed. Amplitude of accommodation, i.e., near point and far point of accommodation, were kept unchanged, although isopropyl unoprostone produced a slight hyperopic shift in dark focus of accommodation. These findings suggest that the reduction of intraocular pressure needs to be explained by a mechanism other than the relaxation of ciliary muscles.
研究了局部应用前列腺素相关化合物异丙前列酮对屈光和调节的影响。局部应用异丙前列酮可明显降低眼压，但未观察到屈光的显著变化。尽管异丙前列酮在调节暗焦点时产生了轻微的远视偏移，但调节幅度，即调节近点和远点保持不变。这些发现表明，眼压降低需要用除睫状肌松弛以外的机制来解释。
