Shimoe Y, Fukutake T, Nakai R, Hirayama K
Department of Neurology, School of Medicine, Chiba University, Japan.
Rinsho Shinkeigaku. 1996 Mar;36(3):495-8.
A 63-year-old man had recurrent spontaneous attacks of consciousness disturbance without toxic, metabolic, or structural brain damage. Interictal electroencephalography showed 14 Hz spindle wave-like activity; ictal electroencephalography revealed faster basic activity. Flumazenil, a benzodiazepine antagonist, promptly resolved the attacks. The endogenous benzodiazepine-like activities in plasma and cerebrospinal fluid (measured in the courtesy of P. Schoch Ph. D, F. Hoffmann-La Roche Ltd, Basel, Switzerland) increased in the interictal period and increased more strikingly in the ictal period. These findings and the clinical effects of flumazenil suggest an involvement of an endogenous benzodiazepine-like activity in the pathogenesis of the attacks in this patient, as same as in a case reported by Tinuper et al (1992).
一名63岁男性反复出现自发性意识障碍发作，无脑毒性、代谢性或结构性损伤。发作间期脑电图显示14赫兹纺锤波样活动；发作期脑电图显示基础活动更快。氟马西尼，一种苯二氮䓬拮抗剂，迅速缓解了发作。血浆和脑脊液中的内源性苯二氮䓬样活性（由瑞士巴塞尔F. Hoffmann-La Roche Ltd的P. Schoch博士友情测定）在发作间期增加，在发作期增加得更显著。这些发现以及氟马西尼的临床效果表明，内源性苯二氮䓬样活性参与了该患者发作的发病机制，与Tinuper等人（1992年）报道的一例病例相同。
