Tinuper P, Montagna P, Cortelli P, Avoni P, Lugaresi A, Schoch P, Bonetti E P, Gallassi R, Sforza E, Lugaresi E
Institute of Neurology, University of Bologna, Italy.
Ann Neurol. 1992 May;31(5):503-6. doi: 10.1002/ana.410310507.
A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma-aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.
一名患者在没有中毒、代谢或结构性脑损伤的情况下反复出现自发性昏迷或木僵发作。发作期脑电图显示14Hz的快速背景活动；睡眠研究排除了发作性睡病。氟马西尼（安易醒），一种苯二氮䓬拮抗剂，迅速缓解了发作并使脑电图恢复正常。放射受体结合研究表明，发作期间血浆和脑脊液中存在与中枢苯二氮䓬受体结合的配体，提示γ-氨基丁酸（GABA）能系统参与了发作的起源。
