Murakami F, Iijima K, Nakamura K, Ikawa S, Hayashibara H, Siraki K
Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
Rinsho Byori. 1996 Jul;44(7):692-6.
In a 2-year-old girl showing purpura on her legs after administration of antibiotics, marked prolongation of activated partial thromboplastin time(APTT) and prothrombin time was noted. Circulating anticoagulants were demonstrated by the failure to correct APTT on neutralization test. A lupus anticoagulant(LA), one of the circulating anticoagulants, was detected by rabbit brain phospholipid neutralization procedure and platelet neutralization procedure. On crossed immunoelectrophoresis, the abnormal prothrombin peaks with reduced electrophoretic mobilities were considered prothrombin/prothrombin-antibody complexes because pretreatment with anti-human IgG serum caused their disappearance. This prothrombin-antibody seemed to be another circulating anticoagulant. The anti-prothrombin-antibody reduced prothrombin activities in the circulating blood of the patient to 20 approximately 30% of normal and the condition persisted for two weeks resulting in the purpura which occurred during that period. After two months, APTT was restored to normal following the disappearance of LA.
一名2岁女童在使用抗生素后腿部出现紫癜，活化部分凝血活酶时间（APTT）和凝血酶原时间显著延长。通过中和试验中APTT未能纠正证实存在循环抗凝物质。通过兔脑磷脂中和试验和血小板中和试验检测到狼疮抗凝物（LA），它是循环抗凝物质之一。在交叉免疫电泳中，电泳迁移率降低的异常凝血酶原峰被认为是凝血酶原/凝血酶原 - 抗体复合物，因为用抗人IgG血清预处理后这些峰消失了。这种凝血酶原抗体似乎是另一种循环抗凝物质。抗凝血酶原抗体将患者循环血液中的凝血酶原活性降低至正常的约20%至30%，这种情况持续了两周，导致在此期间出现紫癜。两个月后，随着LA消失，APTT恢复正常。
