Mwanda O W
Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi.
East Afr Med J. 1998 Oct;75(10):619-20.
A twenty seven year old female was referred to our department with deep vein thrombosis, abnormal activated partial thromboplastin time (aPTT) ratio 1:60 and prothrombin time (PT) INR of 3:11. She had history of loss of pregnancies previously. Coagulation tests with pooled normal fresh plasma did not correct a PTT because of a coagulation inhibitor and only partially corrected PT. Kaolin clotting time (KCT) of patient plasma (PP) and a mixture of PP/normal plasma (NP) detected the lupus anticoagulant (LA). Venereal Disease Laboratory (VDRL) test on the patient's serum was positive with low titre 1:8 while Treponema Pallidum haemaglutination test (TPHA) was negative. Anticardiolipin antibodies IgG were raised while IgM levels were within normal levels. This was a case of lupus anticoagulant syndrome. The patient was treated with unfractionated heparin and warfarin and later started on salicylates and prednisone.
一名27岁女性因深静脉血栓形成、活化部分凝血活酶时间（aPTT）比值异常为1:60以及凝血酶原时间（PT）国际标准化比值为3:11被转诊至我科。她既往有多次流产史。由于存在凝血抑制剂，用混合正常新鲜血浆进行的凝血试验未能纠正PTT，仅部分纠正了PT。患者血浆（PP）以及PP/正常血浆（NP）混合物的高岭土凝血时间（KCT）检测到狼疮抗凝物（LA）。患者血清的性病研究实验室（VDRL）试验呈阳性，滴度较低为1:8，而梅毒螺旋体血凝试验（TPHA）为阴性。抗心磷脂抗体IgG升高，而IgM水平在正常范围内。这是一例狼疮抗凝物综合征病例。该患者接受了普通肝素和华法林治疗，随后开始使用水杨酸盐和泼尼松。
