Odano I, Ohkubo M, Takahashi M, Noguchi E, Ohtaki H, Kasahara T, Hatano M, Sato T
Department of Radiology, Niigata University School of Medicine.
Kaku Igaku. 1996 Jun;33(6):579-86.
To measure distribution volume of 123I-IMP with one-point sampling of arterial blood and 2 times SPECT scans using the Magic square method (Rate constant square method), we introduced a program on a SPECT computer system. In this program four functional images; distribution volume, CBF (K1), k2 and delayed/early ratio, and absolute values with S.D. are obtained on the computer. We have been using the program on daily SPECT studies. In this study we discussed the usefulness of the method. Redistribution phenomenon of 123I-IMP, which is not exactly enough investigated, can be transformed into a functional parameter, distribution volume. Since distribution volume represents an extent of retention of 123I-IMP in brain tissue, it can play an important role to evaluate functional activity in the brain and to diagnose cerebral diseases.
为使用幻方法（速率常数平方法）通过动脉血单点采样和2次SPECT扫描来测量123I-IMP的分布容积，我们在SPECT计算机系统上引入了一个程序。在该程序中，可在计算机上获得四个功能图像：分布容积、脑血流量（K1）、k2以及延迟/早期比值，还有带标准差的绝对值。我们一直在日常SPECT研究中使用该程序。在本研究中，我们讨论了该方法的实用性。123I-IMP的再分布现象尚未得到充分研究，可将其转化为一个功能参数——分布容积。由于分布容积代表123I-IMP在脑组织中的潴留程度，它在评估脑功能活动和诊断脑部疾病方面可发挥重要作用。
