Takahashi N
Department of Radiology, Niigata University School of Medicine, Japan.
Ann Nucl Med. 1994 Nov;8(4):253-8. doi: 10.1007/BF03165028.
A more accurate quantitative method for the measurement of regional cerebral blood flow (rCBF) with the microsphere model and N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) and ring-type single-photon emission computed tomography (SPECT) was developed. Continuous withdrawal of arterial blood was carried out for 5 minutes after the injection. Static SPECT data were acquired from 25 min to 55 min. To estimate reconstructed images at 5 min, total brain count collections and one minute SPECT studies were performed at 5, 20, and 60 min. Quantitative values for rCBF were calculated from short time SPECT images at 5 min (rCBF), static SPECT images corrected by total brain counts (rCBFCt) and those corrected by reconstructed counts on short time SPECT images (rCBFCb). Practically, rCBFCb is calculated by using reconstructed counts of regions of interest placed in the same position as static SPECT and short time SPECT at 5, 20, 60 min. Although there was good correlation between rCBF and rCBFCt (r = 0.69), rCBFCt tended to be underestimated in high flow areas and overestimated in low flow areas. A better correlation was observed between rCBF and rCBFCb (r = 0.92). The overestimation and underestimation observed in rCBFCt was considered to be due to the correction method with a total cerebral time activity curve, because the kinetic behavior of 123I-IMP was different in each region.
开发了一种更准确的定量方法，用于通过微球模型、N-异丙基-p-[123I]碘安非他明（123I-IMP）和环形单光子发射计算机断层扫描（SPECT）测量局部脑血流量（rCBF）。注射后持续抽取动脉血5分钟。在25分钟至55分钟采集静态SPECT数据。为了估计5分钟时的重建图像，在5、20和60分钟进行全脑计数采集和1分钟SPECT研究。rCBF的定量值根据5分钟时的短时间SPECT图像（rCBF）、通过全脑计数校正的静态SPECT图像（rCBFCt）以及通过短时间SPECT图像上的重建计数校正的图像（rCBFCb）计算得出。实际上，rCBFCb是通过使用在5、20、60分钟时与静态SPECT和短时间SPECT处于相同位置的感兴趣区域的重建计数来计算的。尽管rCBF与rCBFCt之间存在良好的相关性（r = 0.69），但rCBFCt在高血流区域往往被低估，而在低血流区域被高估。rCBF与rCBFCb之间观察到更好的相关性（r = 0.92）。rCBFCt中观察到的高估和低估被认为是由于全脑时间-活度曲线的校正方法所致，因为123I-IMP在每个区域的动力学行为不同。
