[肺癌合并特发性间质性肺炎患者的特征与管理]

[Characteristics and management of patients with lung cancer and idiopathic interstitial pneumonia].

作者信息

Takeuchi E, Yamaguchi T, Mori M, Tanaka S, Nakagawa M, Yokota S, Nishikawa H, Noma K, Itoh M, Ogura T

机构信息

Department of Internal Medicine, Toneyama National Hospital, Osaka, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Jun;34(6):653-8.

PMID:8741530

Abstract

Among 102 patients with idiopathic interstitial pneumonia (IIP), 22 with lung cancer who were treated from 1981 to 1994 were studied retrospectively. As controls, 248 patients with lung cancer only who were treated from 1991 to 1992 were also studied. Lung cancer developed in 6 of 85 patients after IIP was diagnosed (7.1%). The time from the onset of IIP to the onset of lung cancer was 7.7 years. In 17 patients both IIP and lung cancer were present on admission. In general, patients with IIP and lung cancer were heavy smokers. In patients with IIP and lung cancer, %VC was higher than in those with IIP alone, and 20 cancers (90.0%) were in peripheral lung fields. Seventeen patients received anticancer chemotherapy, irradiation, or both. Five patients (29.4%) died of respiratory failure due to progression of pneumonitis after the therapy. The prognosis for patients with IIP and lung cancer was very poor.

摘要

在102例特发性间质性肺炎（IIP）患者中，对1981年至1994年期间接受治疗的22例合并肺癌患者进行了回顾性研究。作为对照，还对1991年至1992年期间仅接受治疗的248例肺癌患者进行了研究。85例IIP患者中有6例在诊断IIP后发生肺癌（7.1%）。从IIP发病到肺癌发病的时间为7.7年。17例患者入院时同时存在IIP和肺癌。总体而言，IIP合并肺癌的患者吸烟量大。IIP合并肺癌患者的%VC高于单纯IIP患者，20例癌症（90.0%）位于肺外周区域。17例患者接受了抗癌化疗、放疗或两者皆有。5例患者（29.4%）在治疗后因肺炎进展死于呼吸衰竭。IIP合并肺癌患者的预后非常差。