Meredith G E, Pattiselanno A, Groenewegen H J, Haber S N
Department of Anatomy and Embryology, Vrije Universiteit Faculty of Medicine, Amsterdam, Netherlands.
J Comp Neurol. 1996 Feb 19;365(4):628-39. doi: 10.1002/(SICI)1096-9861(19960219)365:4<628::AID-CNE9>3.0.CO;2-6.
The neurochemical division of the rodent nucleus accumbens into shell and core is now a widely accepted concept. However, such divisions in the primate nucleus accumbens have yet to be fully clarified and described. In the present study, the forebrains of three primates--marmoset, rhesus monkey, and human--and a Wistar rat, were immunoreacted with antibodies directed against calbindin-D28k. The patterns of immunoreactivity in the primates' ventral striatum were mapped and compared to that of rat. Calbindin staining was uneven in all species and there was no evidence of a bicompartmental organization, i.e., striosome/patch and matrix, in central parts of the nucleus. Nucleus accumbens in primates, as in rat, could be divided immunohistochemically into a crescent-shaped outer shell--medially, ventrally and laterally--and an inner core. In general, medial parts of the shell stained less intensely for calbindin than did lateral parts. However, interspecific variation in the intensity of the immunoreactive staining and the mediolateral extent of the shell was obvious. The core, which immunostained unevenly, was consistently more intensely immunoreactive than either medial or lateral shell in all species except the marmoset. These results suggest that the neurochemical subdivisions of shell and core established for nucleus accumbens of rodents are also present in primates. However, further work is needed to establish whether these territories are homologous and, if so, the full extent of that homology.
将啮齿动物伏隔核神经化学划分为壳区和核区，如今已成为一个被广泛接受的概念。然而，灵长类动物伏隔核的这种划分尚未得到充分阐明和描述。在本研究中，用抗钙结合蛋白-D28k抗体对三种灵长类动物（狨猴、恒河猴和人类）以及一只Wistar大鼠的前脑进行免疫反应。绘制了灵长类动物腹侧纹状体的免疫反应模式，并与大鼠的进行比较。钙结合蛋白染色在所有物种中都不均匀，且在核的中央部分没有证据表明存在双区组织，即纹状体小体/斑块和基质。与大鼠一样，灵长类动物的伏隔核在免疫组织化学上可分为新月形的外壳（内侧、腹侧和外侧）和内核。一般来说，壳区的内侧部分钙结合蛋白染色强度低于外侧部分。然而，免疫反应染色强度和壳区内外侧范围的种间差异很明显。除狨猴外，内核免疫染色不均匀，在所有物种中其免疫反应性始终比内侧或外侧壳区更强。这些结果表明，在啮齿动物伏隔核中建立的壳区和核区的神经化学细分在灵长类动物中也存在。然而，需要进一步研究来确定这些区域是否同源，如果是，同源的完整程度如何。
