Sengupta P, Bargmann C I
Department of Anatomy, University of California, San Francisco, USA.
Dev Genet. 1996;18(1):73-80. doi: 10.1002/(SICI)1520-6408(1996)18:1<73::AID-DVG8>3.0.CO;2-Z.
Neuronal cell fates are specified by a hierarchy of events mediated by cell-intrinsic determinants and cell-cell interactions. The determination of cell fate can be subdivided into three general steps. First, cell fate is restricted by the cell's position in the animal. For example, neurons are specified along the anterior-posterior body axis through the action of the Hox genes lin-39, mab-5, and egl-5. Second, a decision is made to generate a particular cell type, such as the progenitor of a neurogenic lineage as opposed to that of an epidermal lineage. Among the genes that influence this decision is the proneural gene lin-32. Third, characteristics of a particular cell type are specified. For example, in a neurogenic lineage, a decision may be made to generate a specific neuron type such as a sensory or motor neuron. Genes that affect neuronal fate can act in different ways to influence the development of different types of neurons.
神经元细胞命运由细胞内在决定因素和细胞间相互作用介导的一系列事件所决定。细胞命运的决定可细分为三个一般步骤。首先，细胞命运受其在动物体内位置的限制。例如，神经元通过Hox基因lin-39、mab-5和egl-5的作用沿前后体轴被指定。其次，做出产生特定细胞类型的决定，例如神经源性谱系的祖细胞而非表皮谱系的祖细胞。影响这一决定的基因中有原神经基因lin-32。第三，特定细胞类型的特征被指定。例如，在神经源性谱系中，可能会做出产生特定神经元类型（如感觉或运动神经元）的决定。影响神经元命运的基因可以以不同方式作用，以影响不同类型神经元的发育。
