Tritapepe R, Cesana B
Cattedra di Chirurgia dell'Apparato Digerente, Università degli Studi di Milano, Italy.
Ital J Gastroenterol. 1996 Jan;28(1):20-4.
This in vitro study compared the gallstone dissolution rates of mono-octanoin, mono-octanoin plus 10% distilled water, and mono-octanoin plus methyl tert-butyl ether 2:1. Sixteen stones were treated with each solvent at a slow perfusion rate of 3-4 ml/h and a rapid perfusion rate of 2.5 ml/30 min with 20-sec instillation/aspiration cycles, both with and without bile. The stones were weighed before, and 3, 6, 12 and 24 hrs after the start of treatment: the solvent was changed every 30 min. After 24 hrs of instillation/aspiration without bile, the mono-octanoin/methyl tert-butyl ether mixture reduced the weight of the stones by 93%, mono-octanoin plus water by 63%, and mono-octanoin alone by 52%; with bile, the figures were, respectively, 86%, 42% and 40%. The mono-octanoin/methyl tert-butyl ether mixture thus took approximately half the time needed by the other two preparations to dissolve the stones to the same extent, a finding which may be relevant for the clinical dissolution of bile duct stones.
这项体外研究比较了单辛脂、单辛脂加10%蒸馏水以及单辛脂与甲基叔丁基醚按2:1比例混合后的溶石率。分别用这三种溶剂以3 - 4毫升/小时的慢速灌注速率以及2.5毫升/30分钟的快速灌注速率（伴随20秒滴注/抽吸循环）处理16颗结石，处理过程中分别添加和不添加胆汁。在治疗开始前以及治疗开始后的3小时、6小时、12小时和24小时对结石进行称重：每30分钟更换一次溶剂。在无胆汁的情况下进行24小时滴注/抽吸后，单辛脂/甲基叔丁基醚混合物使结石重量减轻了93%，单辛脂加水使结石重量减轻了63%，单辛脂单独使用使结石重量减轻了52%；在有胆汁的情况下，相应数字分别为86%、42%和40%。因此，单辛脂/甲基叔丁基醚混合物将结石溶解至相同程度所需的时间大约是其他两种制剂的一半，这一发现可能与胆管结石的临床溶解有关。
