Kandiah D A, Krilis S A
Department of Immunology, Allergy and Infectious Disease, University of New South Wales, St George Hospital, Kogarah, Australia.
Lupus. 1996 Apr;5(2):153-5. doi: 10.1177/096120339600500212.
'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to be directed against negatively-charged (anionic) phospholipids current evidence suggests that these autoantibodies recognise protein-phospholipid complexes or the proteins themselves. A number of candidate proteins have been investigated with the two most extensively researched being beta 2-glycoprotein I and prothrombin.
“抗磷脂”（aPL）抗体具有临床重要性，因为它们与血管血栓形成、复发性流产、血小板减少以及其他临床表现如网状青斑、舞蹈症和心脏瓣膜病密切相关。虽然传统上认为aPL抗体是针对带负电荷（阴离子）的磷脂，但目前的证据表明，这些自身抗体识别蛋白质-磷脂复合物或蛋白质本身。已经研究了许多候选蛋白质，其中研究最广泛的两种是β2糖蛋白I和凝血酶原。
