Weinstein S
J Invest Dermatol. 1977 Jul;69(1):136-45. doi: 10.1111/1523-1747.ep12497932.
New, reliable, and precise methods for measuring absolute pressure sensitivity in mucous membranes and on intact skin are described. Studies were conducted to determine how local anesthetics (phenol and sodium phenolate and Benzocaine) affect tactile sensitivity thresholds in the oropharynx and on the intact skin of the volar surface of the forearms, ankles, knees, elbows, and dorsum of the hands. Gargling and expectorating a solution containing phenol had a significantly greater anesthetic effect on the mucous membranes of the oropharynx than spraying and swallowing, which, in turn, had a greater effect than drinking the solution. Compared with ethanol and petroleum jelly (Vaseline), the topical application of Benzocaine (0, .5, 1, 3, and 5% solutions in 100% ethanol) significantly increased the tactile sensory thresholds on the volar surface of the forearm. A highly significant loss of tactual sensitivity of the oropharynx was demonstrated in smokers.
本文描述了用于测量粘膜和完整皮肤上绝对压力敏感性的新型、可靠且精确的方法。开展了多项研究，以确定局部麻醉剂（苯酚、酚钠和苯佐卡因）如何影响口咽以及前臂掌侧、脚踝、膝盖、肘部和手背完整皮肤上的触觉敏感性阈值。含苯酚溶液的漱口和咳出对口咽粘膜的麻醉效果显著大于喷雾和吞咽，而喷雾和吞咽又比饮用该溶液的效果更佳。与乙醇和凡士林相比，苯佐卡因（100%乙醇中的0、0.5、1、3和5%溶液）的局部应用显著提高了前臂掌侧的触觉感觉阈值。吸烟者口咽的触觉敏感性出现了高度显著的丧失。
