Nielsen S, Marples D, Frøkiaer J, Knepper M, Agre P
Department of Cell Biology, University of Aarhus, Denmark.
Kidney Int. 1996 Jun;49(6):1718-23. doi: 10.1038/ki.1996.254.
The long-standing problem of membrane water transport has been advanced by the recognition of a new family of water transport proteins, the "aquaporins" [1-3]. Not surprisingly, water transport is a major process in kidney physiology, and the biology of aquaporins is most thoroughly understood in that organ. We reviewed in detail the status of aquaporins in the kidney only one year ago [4], but the subsequent progress has dictated the need for an update. This seems especially appropriate in honor of the 100th birthday of Homer Smith, the pioneer whose foresight initiated this field.
对一类新的水转运蛋白“水通道蛋白”的认识推动了长期存在的膜水转运问题的研究进展[1 - 3]。毫不奇怪，水转运是肾脏生理学中的一个主要过程，并且水通道蛋白的生物学特性在该器官中得到了最深入的了解。仅仅在一年前，我们还详细回顾了肾脏中水通道蛋白的状况[4]，但随后的进展表明有必要进行更新。鉴于荷马·史密斯诞辰100周年，进行这样的更新似乎尤为合适，他是开创这一领域的先驱，具有卓越的远见。
