Subramanian P, Subbaraj R
Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, India.
Pharmacol Biochem Behav. 1996 Jun;54(2):393-8. doi: 10.1016/0091-3057(95)02079-9.
Experiments were carried out on the continuous action of diazepam (benzodiazepine) offered through drinking water in 2% ethanol on psi and tau of the activity rhythms under LD (12:12) and DD conditions. Under entraining conditions diazepam failed to evoke striking changes in psi. On the other hand, under free-running conditions period-lengthening and period-shortening effects were observed. Further experiments conducted on the continuous effect of diazepam on light pulse evoked phase shifts revealed that phase advances were attenuated significantly in diazepam-treated animals at CT 20 and 24. These results were discussed with regard to the action of diazepam on the light sensitivity of the circadian pacemaker.
实验在LD（12:12）和DD条件下，通过在2%乙醇饮用水中提供地西泮（苯二氮䓬）对活动节律的ψ和τ进行连续作用研究。在同步条件下，地西泮未能引起ψ的显著变化。另一方面，在自由运行条件下，观察到周期延长和周期缩短效应。进一步关于地西泮对光脉冲诱发相移的连续作用实验表明，在CT 20和24时，地西泮处理的动物中相提前显著减弱。结合地西泮对昼夜节律起搏器光敏感性的作用对这些结果进行了讨论。
