Pietrzak B, Czarnecka E
Department of Pharmacodynamics, Medical University, Lódź, Poland.
Pharmazie. 2005 Oct;60(10):761-4.
The mechanism of action of benzodiazepines and ethanol demonstrates that these agents can synergistically affect the central nervous system (CNS). The effects of both ethanol and diazepam are likely to depend on the time of the day when they were administered. Diazepam influence on ethanol-induced sleeping and hypothermic activity in mice as well as the influence of combined administration of these agents on spontaneous locomotor activity and coordination in mice (rota-rod) were investigated. Experiments were carried out in the light phase (10:00-12:00 h) and the dark phase (22:00-24:00 h). It was shown that ethanol-induced sleeping time was longer in the dark phase than the light phase, and that ethanol increased spontaneous locomotor activity both in the light and the dark. Ethanol-induced hypothermia was lower in the dark than in the light. Diazepam decreased locomotor activity more strongly in the dark phase than by day. It impaired the hypothermic action of ethanol in the light phase, but did not have such an effect in the dark phase. Diazepam prolonged ethanol-induced sleep in the light phase, enhanced its action on locomotor coordination and decreased the stimulating effect of ethanol on spontaneous locomotor activity in mice. The chronobiological effect of the interaction between diazepam and ethanol seems to be of practical importance (sleep and motor coordination).
苯二氮䓬类药物和乙醇的作用机制表明，这些药物可协同影响中枢神经系统（CNS）。乙醇和地西泮的作用可能取决于给药的时间。研究了地西泮对乙醇诱导的小鼠睡眠和体温过低活动的影响，以及这些药物联合给药对小鼠自发运动活动和协调性（转棒试验）的影响。实验在光照期（10:00 - 12:00 h）和黑暗期（22:00 - 24:00 h）进行。结果表明，乙醇诱导的睡眠时间在黑暗期比光照期更长，并且乙醇在光照期和黑暗期均增加自发运动活动。乙醇诱导的体温过低在黑暗期比光照期更低。地西泮在黑暗期比白天更强烈地降低运动活动。它在光照期削弱了乙醇的体温过低作用，但在黑暗期没有这种作用。地西泮在光照期延长了乙醇诱导的睡眠，增强了其对运动协调性的作用，并降低了乙醇对小鼠自发运动活动的刺激作用。地西泮与乙醇相互作用的时间生物学效应似乎具有实际重要性（睡眠和运动协调性）。
