McConnell K, Dynan W S
Medical College of Georgia, Institute for Molecular medicine & Genetics, Augusta 30912-3175, USA.
Curr Opin Cell Biol. 1996 Jun;8(3):325-30. doi: 10.1016/s0955-0674(96)80005-6.
The catalytic subunit of the DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol 3-kinase family. Recent genetic and biochemical studies indicate the involvement of DNA-PK in immunoglobulin/T-cell-receptor gene recombination, double-strand DNA break repair, the stress response and autoimmunity. A role in the suppression of apoptosis could link some of the enzyme's diverse functions.
DNA依赖性蛋白激酶（DNA-PK）的催化亚基是磷脂酰肌醇3激酶家族的成员。最近的遗传学和生物化学研究表明，DNA-PK参与免疫球蛋白/T细胞受体基因重组、双链DNA断裂修复、应激反应和自身免疫。其在抑制细胞凋亡中的作用可能将该酶的一些不同功能联系起来。
