DNA双链断裂修复与V(D)J重组：DNA依赖蛋白激酶的作用
DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.
作者信息
Jackson S P, Jeggo P A
机构信息
Wellcome/CRC Institute, Cambridge, UK.
出版信息
Trends Biochem Sci. 1995 Oct;20(10):412-5. doi: 10.1016/s0968-0004(00)89090-8.
PMID:8533154
Abstract
Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.
摘要
涉及DNA双链断裂（DSB）的两个过程是电离辐射诱导的DNA损伤修复以及V（D）J重组，后者是在脊椎动物中产生抗原受体多样性的基因组重排。最近的证据表明，被DNA末端激活的DNA依赖性蛋白激酶（DNA-PK）是DNA双链断裂修复和V（D）J重组机制的核心组成部分。
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