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Kinetochore function: molecular motors, switches and gates.

作者信息

Yen T J, Schaar B T

机构信息

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

出版信息

Curr Opin Cell Biol. 1996 Jun;8(3):381-8. doi: 10.1016/s0955-0674(96)80014-7.

DOI:10.1016/s0955-0674(96)80014-7
PMID:8743891
Abstract

Kinetochores are essential for accurate chromosome segregation. Recent studies reveal that vertebrate kinetochores are sophisticated propulsion systems composed of not only force generators but also "navigation' and "fail-safe' mechanisms. Advances toward the understanding of the biochemical composition and activities of the components of the kinetochore have come from the molecular characterization of key proteins of the kinetochore complex.

摘要

相似文献

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Motors involved in spindle assembly and chromosome segregation.参与纺锤体组装和染色体分离的马达蛋白。
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Kinetochore-microtubule interactions in chromosome segregation: lessons from yeast and mammalian cells.染色体分离中动粒与微管的相互作用：来自酵母和哺乳动物细胞的经验教训。
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引用本文的文献

1
Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs.小鼠卵母细胞减数分裂II后期着丝粒非依赖的染色体向极运动。
PLoS One. 2009;4(4):e5249. doi: 10.1371/journal.pone.0005249. Epub 2009 Apr 13.
2
Human chromokinesin KIF4A functions in chromosome condensation and segregation.人类染色体驱动蛋白KIF4A在染色体凝聚和分离过程中发挥作用。
J Cell Biol. 2004 Aug 30;166(5):613-20. doi: 10.1083/jcb.200401142. Epub 2004 Aug 23.
3
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.
人类BUBR1是一种有丝分裂检查点激酶，可监测动粒处的CENP-E功能，并与细胞周期体/后期促进复合物结合。
J Cell Biol. 1999 Sep 6;146(5):941-54. doi: 10.1083/jcb.146.5.941.
4
Chromosomal strategies for adaptation to univalency.适应单价体的染色体策略。
Chromosome Res. 1998 Nov;6(7):515-31. doi: 10.1023/a:1009259804652.
5
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.哺乳动物的p55CDC介导纺锤体检查点蛋白Mad2与细胞周期体/后期促进复合体的结合，并参与调控后期起始和有丝分裂后期事件。
J Cell Biol. 1998 Jun 15;141(6):1393-406. doi: 10.1083/jcb.141.6.1393.
6
Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles.在非洲爪蟾提取物纺锤体中，后期A染色体移动和向极纺锤体微管通量以相似的速率发生。
J Cell Biol. 1998 May 4;141(3):703-13. doi: 10.1083/jcb.141.3.703.
7
CENP-E function at kinetochores is essential for chromosome alignment.着丝粒蛋白E（CENP-E）在动粒处的功能对于染色体排列至关重要。
J Cell Biol. 1997 Dec 15;139(6):1373-82. doi: 10.1083/jcb.139.6.1373.
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Neocentromere-mediated chromosome movement in maize.玉米中着丝粒介导的染色体运动。
J Cell Biol. 1997 Nov 17;139(4):831-40. doi: 10.1083/jcb.139.4.831.
9
CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II.着丝粒蛋白E（CENP-E）是成熟卵母细胞中一种必需的动粒马达蛋白，在依赖mos的中期II期细胞周期停滞期间被掩盖。
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9165-70. doi: 10.1073/pnas.94.17.9165.