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[用胶体金免疫探针检测抗梅毒螺旋体抗体]

[Detection of anti-Treponema pallidum antibodies with colloidal gold immunoprobes].

作者信息

Burgos J D, Mendoza M, Vinasco J, Hernández R

机构信息

Laboratorio Biotecnológico, Universidad INCCA de Colombia, Bogotá, S. América.

出版信息

Enferm Infecc Microbiol Clin. 1996 May;14(5):304-7.

PMID:8744370
Abstract

BACKGROUND

The aim of this study was to evaluate the usefulness of colloidal gold probes widely used in histochemistry and electronic microscopy for the serologic diagnosis of syphilis.

METHODS

One hundred eighty-nine sera which had been submitted to the traditional fluorescent trigenemic absorption (FTA-ABS) test and had later been tested with the new colloidal gold probe method (IAT-ABS).

RESULTS

Out of a total of 103 positive samples by FTA-ABS all were positive when tested by gold immunoprobes (sensitivity 100%). Eighty-six samples which were negative by immunofluorescence were all negative by IAT-ABS (specificity 100%).

CONCLUSIONS

The new method of colloidal gold probes with the current microscopy is useful for confirming serologic diagnosis of syphilis.

摘要

背景

本研究的目的是评估广泛应用于组织化学和电子显微镜的胶体金探针在梅毒血清学诊断中的效用。

方法

189份血清样本先进行传统的荧光螺旋体抗体吸收试验（FTA-ABS），随后再用新的胶体金探针法（IAT-ABS）检测。

结果

FTA-ABS检测的103份阳性样本，用金免疫探针检测时全部为阳性（敏感性100%）。免疫荧光检测为阴性的86份样本，IAT-ABS检测也全部为阴性（特异性100%）。

结论

结合当前显微镜技术的新型胶体金探针法有助于确诊梅毒的血清学诊断。

相似文献

1
[Detection of anti-Treponema pallidum antibodies with colloidal gold immunoprobes].[用胶体金免疫探针检测抗梅毒螺旋体抗体]
Enferm Infecc Microbiol Clin. 1996 May;14(5):304-7.
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Evaluation of a colloidal gold immunochromatography assay in the detection of Treponema pallidum specific IgM antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis.胶体金免疫层析法检测梅毒血清固定患者梅毒螺旋体特异性 IgM 抗体的评价：梅毒复发和感染的血清学标志物。
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Development of a colloidal gold-immunochromatography assay to detect immunoglobulin G antibodies to Treponema pallidum with TPN17 and TPN47.建立胶体金免疫层析法检测梅毒螺旋体 IgG 抗体 TPN17 和 TPN47
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Rapid detection of specific treponemal antibodies by counterimmunoelectrophoresis using an extract of Treponema pallidum.使用梅毒螺旋体提取物通过对流免疫电泳快速检测特异性梅毒螺旋体抗体。
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[Cause and method of eliminating "nonspecific" immunofluorescence of Treponema pallidum. Nonspecific results of the IgM-FTA-ABS test].
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7
[The cause and method of removing non-specific immunofluorescence in Treponema pallidum. II. Non-specific positive results of the FTA and FTA-ABS tests in various pathological and physiological conditions].梅毒螺旋体非特异性免疫荧光的产生原因及去除方法。II. 各种病理和生理条件下FTA及FTA-ABS试验的非特异性阳性结果
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[Serologic test for syphilis (STS, FTA-ABS, IgM-FTA-ABS, and TPHA)].[梅毒血清学检测（梅毒血清试验、荧光密螺旋体抗体吸收试验、IgM 荧光密螺旋体抗体吸收试验和梅毒螺旋体血凝试验）]
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[Comparison of methods for the demonstration of Treponema-specific IgM].[梅毒螺旋体特异性IgM检测方法的比较]
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[Fluorescence-immunological syphilis diagnosis (FTA and FTA-ABS test) (proceedings)].[荧光免疫梅毒诊断（FTA和FTA - ABS试验）（会议记录）]
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