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梅毒螺旋体抗体微量血凝试验(MHA-TP),一种新的梅毒螺旋体检测方法:它的适用情况如何?

The microhemagglutination assay for Treponema pallidum antibodies (MHA-TP), a new treponemal test for syphilis: where does it fit?

作者信息

Rudolph A H

出版信息

J Am Vener Dis Assoc. 1976 Sep;3(1):3-8.

PMID:795798
Abstract

The status of a new treponemal test, the Microhemagglutination Assay for Treponema pallidum Antibodies (MHA-TP) is reviewed and compared with regard to its sensitivity, specificity, and current clinical application to the VDRL slide test, the most widely used non-treponemal test, and to the manual FTA-ABS test, the standard treponemal test. At present, the MHA-TP test seems to combine the simplicity and lower cost of nontreponemal tests and the sensitivity and specificity of treponemal tests, and thus enjoys features of both a screening and verification procedure. However, additional clinical experience with the test is needed before its role in the serologic diagnosis of syphilis can be conclusively determined.

摘要

对一种新的梅毒螺旋体检测方法——梅毒螺旋体抗体微量血凝试验(MHA - TP)的现状进行了综述,并就其敏感性、特异性以及目前在临床应用中与最广泛使用的非梅毒螺旋体检测方法——性病研究实验室玻片试验(VDRL)和标准梅毒螺旋体检测方法——手工荧光密螺旋体抗体吸收试验(FTA - ABS)进行了比较。目前,MHA - TP试验似乎兼具非梅毒螺旋体检测方法的简便性和低成本以及梅毒螺旋体检测方法的敏感性和特异性,因此具有筛查和验证程序的特点。然而,在最终确定其在梅毒血清学诊断中的作用之前,还需要更多的临床经验。

相似文献

1
The microhemagglutination assay for Treponema pallidum antibodies (MHA-TP), a new treponemal test for syphilis: where does it fit?梅毒螺旋体抗体微量血凝试验(MHA-TP),一种新的梅毒螺旋体检测方法:它的适用情况如何?
J Am Vener Dis Assoc. 1976 Sep;3(1):3-8.
2
Evaluation of the passive particle agglutination test in the serodiagnosis and follow-up of syphilis.梅毒血清学诊断及随访中被动颗粒凝集试验的评估
Am J Clin Pathol. 2001 Oct;116(4):581-5. doi: 10.1309/9TCQ-B1TA-38MV-R6UM.
3
Comparison of the microhemagglutination assay for antibodies to Treponema pallidum and the automated fluorescent treponemal antibody-absorption test.梅毒螺旋体抗体微量血凝试验与自动化梅毒螺旋体抗体吸收试验的比较。
Health Lab Sci. 1975 Jan;12(1):20-7.
4
Evaluation of the microenzyme-linked immunosorbent assay with Treponema pallidum antigen.用梅毒螺旋体抗原评估微酶联免疫吸附测定法。
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[Passive microhemagglutination reaction to Treponema pallidum in the cerebrospinal fluid in the diagnosis of neurosyphilis].[脑脊液中梅毒螺旋体被动微量血凝反应在神经梅毒诊断中的应用]
Arq Neuropsiquiatr. 1988 Dec;46(4):369-73. doi: 10.1590/s0004-282x1988000400005.
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Evaluation of the qualitative and automated quantitative microhemagglutination assay for antibodies to Treponema pallidum.梅毒螺旋体抗体定性及自动定量微血凝试验的评估
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Specificity, sensitivity, and reproducibility among the fluorescent treponemal antibody-absorption test, the microhemagglutination assay for Treponema pallidum antibodies, and the hemagglutination treponemal test for syphilis.荧光密螺旋体抗体吸收试验、梅毒螺旋体抗体微量血凝试验和梅毒血凝试验之间的特异性、敏感性和可重复性。
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Tests for treponemal antibody in CSF.脑脊液中梅毒螺旋体抗体检测
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Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis.梅毒螺旋体颗粒凝集血清学检测、Murex梅毒ICE检测及Enzywell TP检测用于梅毒血清学诊断的评估。
Int J STD AIDS. 2005 Apr;16(4):294-8. doi: 10.1258/0956462053654195.
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Evaluation of the fluorescent treponemal antibody absorption test for detection of antibodies (immunoglobulins G and M) to Treponema pallidum in serologic diagnosis of syphilis.荧光密螺旋体抗体吸收试验用于梅毒血清学诊断中检测抗梅毒螺旋体抗体(免疫球蛋白G和M)的评估。
Int J STD AIDS. 2007 Apr;18(4):255-60. doi: 10.1258/095646207780658827.

引用本文的文献

1
The endemic treponematoses.地方性梅毒螺旋体病。
Clin Microbiol Rev. 2014 Jan;27(1):89-115. doi: 10.1128/CMR.00070-13.
2
Biological basis for syphilis.梅毒的生物学基础。
Clin Microbiol Rev. 2006 Jan;19(1):29-49. doi: 10.1128/CMR.19.1.29-49.2006.
3
Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.梅毒:重点关注临床、流行病学及一些生物学特征的综述。
Clin Microbiol Rev. 1999 Apr;12(2):187-209. doi: 10.1128/CMR.12.2.187.
4
Modern neurosyphilis: a partially treated chronic meningitis.现代神经梅毒:一种部分治疗的慢性脑膜炎。
West J Med. 1981 Sep;135(3):191-200.
5
Quantitative microhaemagglutination assay for Treponema pallidum antibodies in experimental syphilis.实验性梅毒中梅毒螺旋体抗体的定量微量血凝试验
Br J Vener Dis. 1980 Oct;56(5):291-6. doi: 10.1136/sti.56.5.291.
6
Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, and venereal disease research laboratory tests in primary syphilis.一期梅毒中微量血凝试验、荧光密螺旋体抗体吸收试验及性病研究实验室试验的反应性
J Clin Microbiol. 1980 Oct;12(4):629-30. doi: 10.1128/jcm.12.4.629-630.1980.
7
Recent observations on the serology of syphilis.梅毒血清学的近期观察
Br J Vener Dis. 1980 Feb;56(1):12-6. doi: 10.1136/sti.56.1.12.
8
Reactivity of microhemagglutination, fluorescent treponemal antibody absorption, Venereal Disease Research Laboratory, and rapid plasma reagin tests in primary syphilis.一期梅毒中微量血凝试验、荧光密螺旋体抗体吸收试验、性病研究实验室试验及快速血浆反应素试验的反应性
J Clin Microbiol. 1983 Mar;17(3):405-9. doi: 10.1128/jcm.17.3.405-409.1983.
9
Evaluation of microhaemagglutination assay to determine treponemal antibodies in CSF.评估微量血凝试验以测定脑脊液中的梅毒螺旋体抗体。
Br J Vener Dis. 1979 Aug;55(4):239-44. doi: 10.1136/sti.55.4.239.
10
Specificity of the FTA-ABS and TPHA tests during pregnancy.妊娠期间梅毒螺旋体血细胞凝集试验(FTA - ABS)和梅毒螺旋体血凝试验(TPHA)的特异性。
Br J Vener Dis. 1978 Oct;54(5):295-8. doi: 10.1136/sti.54.5.295.