Shen R N, Lu L, Jia X Q, Wong M L, Kaiser H E
Department of Medicine, Indiana University School of Medicine, Indianapolis 16202-5121, USA.
In Vivo. 1996 Mar-Apr;10(2):201-9.
A number of traditional Chinese medicinal herbs have become extremely interesting in the search for potential BRMs in the international medical community, especially in the United States and Japan. Naturin, a new Chinese medical herb produced by XingYa Pharmaceutical Co., Ltd., has enhanced immune response, inhibited tumor metastases and retroviral infection in animal models as well as in clinical studies. The results demonstrated that the inhibition of Natural Killer (NK) and Lymphokine-activated Killer (LAK) cell activity and lymphocyte proliferation was compromised by tumor metastases and retrovirus infection (Murine AIDS), even immunosuppression induced by surgical amputation can be restored by Naturin. It is also shown that Naturin can protect the mice from lethal total body irradiation. These studies indicated that Naturin possesses immunomodulatory effects in vivo for a broad range of stresses. The results of the clinical studies on Naturin have demonstrated: (a) significantly improved symptoms of patients, including MDS, acute and chronic leukemia, aplastic anemia, lung cancer, and association with the increased number and percentage of CD4 (Helper T-cell) which have been reduced in some patients, (b) Lymphocyte proliferation and NK cell activity which were suppressed in cancer patients can be significantly restored by Naturin treatment, (c) the addition of Naturin treatment to patients receiving radiotherapy and chemotherapy augments immune response and reduces radiation and chemotherapy injury, and (d) no cytotoxic side effects were found in patients given Naturin treatment for up to eight months.
在国际医学界，尤其是在美国和日本，许多传统中草药在寻找潜在生物反应调节剂（BRM）方面变得极具吸引力。兴亚制药有限公司生产的一种新型中草药“Naturin”，在动物模型以及临床研究中均增强了免疫反应、抑制了肿瘤转移和逆转录病毒感染。结果表明，肿瘤转移和逆转录病毒感染（鼠类艾滋病）会损害自然杀伤（NK）细胞和淋巴因子激活的杀伤（LAK）细胞活性以及淋巴细胞增殖，甚至手术截肢诱导的免疫抑制也能被“Naturin”恢复。还表明“Naturin”能保护小鼠免受致死性全身照射。这些研究表明“Naturin”在体内对多种应激具有免疫调节作用。关于“Naturin”的临床研究结果表明：（a）患者症状显著改善，包括骨髓增生异常综合征、急慢性白血病、再生障碍性贫血、肺癌，且一些患者中减少的CD4（辅助性T细胞）数量和百分比增加；（b）“Naturin”治疗可使癌症患者中被抑制的淋巴细胞增殖和NK细胞活性显著恢复；（c）在接受放疗和化疗的患者中添加“Naturin”治疗可增强免疫反应并减少放疗和化疗损伤；（d）接受“Naturin”治疗长达八个月的患者未发现细胞毒性副作用。
