Naughton P J, Grant G, Ewen S W, Spencer R J, Brown D S, Pusztai A, Bardocz S
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK.
FEMS Immunol Med Microbiol. 1995 Dec;12(3-4):251-8. doi: 10.1111/j.1574-695X.1995.tb00200.x.
The effects of infection by Salmonella enteritidis and S. typhimurium on the small and large intestines, liver, spleen and mesenteric nodules of rats were studied in vivo. Both Salmonella serotypes persisted and proliferated in the gastrointestinal tract and invaded sub-epithelial tissues, mainly the ileum, leading to the systemic distribution of these pathogens. Coincidental with infection, the rate of crypt cell proliferation increased resulting in substantial growth of the small intestine. The extent of this and the accompanying accumulation of polyamines was particularly dramatic in the ileum where there was also some disruption of the villus epithelium. It is possible that these effects of the infection on the metabolism and morphology of the small bowel, which strongly resembled the changes induced by some plant lectins, may facilitate the colonisation and invasion of the gut by Salmonellae.
在体内研究了肠炎沙门氏菌和鼠伤寒沙门氏菌感染对大鼠小肠、大肠、肝脏、脾脏和肠系膜淋巴结的影响。两种血清型沙门氏菌均在胃肠道中持续存在并增殖，并侵入上皮下组织，主要是回肠，导致这些病原体在全身分布。与感染同时发生的是，隐窝细胞增殖率增加，导致小肠大量生长。这种情况以及多胺的伴随积累在回肠尤为显著，回肠的绒毛上皮也有一些破坏。感染对小肠代谢和形态的这些影响与某些植物凝集素诱导的变化非常相似，可能有助于沙门氏菌在肠道内的定殖和侵袭。
