Naughton P J, Grant G, Spencer R J, Bardocz S, Pusztai A
Division of Nutritional Sciences, Rowett Research Institute, Bucksburn, Aberdeen, UK.
J Appl Bacteriol. 1996 Dec;81(6):651-6. doi: 10.1111/j.1365-2672.1996.tb03560.x.
Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.
大鼠沙门氏菌病与人类的这种疾病有许多相似之处，回肠被认为是这两个物种中主要的定植/入侵部位。因此，大鼠可能是研究这些病原菌感染机制的一种有用方式。对带帽利斯特大鼠进行的一系列感染试验表明，沙门氏菌感染会持续较长时间，并且沙门氏菌早在胃内插管后4小时就会与小肠上皮细胞结合。因此，来自大肠的再次感染最初可能在沙门氏菌感染过程中不起重要作用。因此，大鼠模型可能提供一种手段来测试旨在阻断病原体在胃肠道中结合的体内干预策略。
